胆瘘是肝切除术后常见并发症。我刊最近在线发表了法国蒙彼利埃大学FabrizioPanaro教授及其团队文章,探讨肝切除术后胆瘘发生的危险因素。该中心回顾分析了例肝切除术患者,术后总体胆瘘发生率为10.2%,研究表明与解剖切除相比,楔形切除会导致更高的胆瘘发生率(25.6%vs4.1%,P0.),而术中全肝血流阻断(TVE)也会增加肝切除术后胆瘘风险(P=0.)。
同时,研究认为残肝质量与术后胆瘘发生率没有明显关联,一些生物密封制剂的运用并没有发现明显益处。这一大型单中心回顾性研究视角新颖,或能给临床带来启发。
Abstract:
Background:Theprimaryfocusofthestudywastoanalyzetheriskfactorsforbileleakageafterhepatectomyforbenignormalignanttumors.
Methods:AtotalofpatientswhohadundergonehepatectomybetweenDecemberandDecemberwereretrospectivelyanalyzed.TheseverityofbileleakagewasgradedaccordingtotheISGLSclassification.Twenty-eightpre-andpostoperativeparameterswereanalyzed.
Results:Theoverallbileleakageincidencewas10.2%(42/).TheseverityoftheleakagewasclassifiedaccordingtotheISGLSclassification.Bileleakagewasdetectedearlyincaseofabdominaldrainage(11.4%vs1.9%,P=0.).Itprolongedthetimeofhospitalization(16vs9days,P=0.).Inallpatients,wedgeresectionwasassociatedwithahigherincidenceofbileleakageincontrasttoanatomicalresections(25.6%vs4.1%,P0.)regardlessoftheunderlyingliverdisease.Furthermore,totalvascularexclusionincreasedriskofbileleakage(P=0.).
Conclusions:Bileleakageasamajorissueafterhepaticresectionisrelatedtothepostoperativemorbidityandthehospitalizationtime.Itisassociatedwithnon-anatomicalresectionandatotalvascularexclusion.
PanaroF,HacinaL,BouyabrineH,Al-HashmiA,HerreroA,NavarroF.Riskfactorsforpostoperativebileleakage:aretrospectivesingle-centeranalysisofhepatectomies.HepatobiliaryPancreatDisInt;September17.doi:10./S-(15)-6.
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